› 5ijh

X-ray diffraction
2.43Å resolution

Structure of the SPX domain of the human phosphate transporter XPR1 in complex with a sulfate ion

Released:
DOI: 10.2210/pdb5ijh/pdb
PDB 5ijh coloured by chain and viewed from the front.
PDB 5ijh coloured by chain and viewed from the side.
PDB 5ijh coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A
Science 352 986-90 (2016)
PMID: 27080106

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Xenotropic and polytropic retrovirus receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 25.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UBH6 (Residues: 1-207; Coverage: 30%)
Gene names: SYG1, XPR1, XR
Sequence domains: SPX domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 65.95Å b: 80.32Å c: 97.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.244
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

50 review citations

Primary nutrient sensors in plants.
Podar et al. (2022)
49 more