› 5iiu

X-ray diffraction
2.3Å resolution

Crystal structure of Equine Serum Albumin in the presence of 10 mM zinc at pH 6.9

Released:
DOI: 10.2210/pdb5iiu/pdb
PDB 5iiu coloured by chain and viewed from the front.
PDB 5iiu coloured by chain and viewed from the side.
PDB 5iiu coloured by chain and viewed from the top.
Source organism: Equus caballus
Primary publication:
Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.
Handing KB, Shabalin IG, Kassaar O, Khazaipoul S, Blindauer CA, Stewart AJ, Chruszcz M, Minor W
Chem Sci 7 6635-6648 (2016)
PMID: 28567254

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.77 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P35747 (Residues: 25-607; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand ZN 10 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P61
Unit cell:
a: 93.746Å b: 93.746Å c: 141.789Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.179 0.24

Quick links

Citations

8 review citations

Albumin Substitution in Decompensated Liver Cirrhosis: Don't Forget Zinc.
Grüngreiff et al. (2021)
7 more

3 mentions without citation

Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.
Handing et al. (2016)
2 more