5ihc

X-ray diffraction
2.14Å resolution

Function and Biology Details

Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-172082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maternal embryonic leucine zipper kinase Chain: A
Molecule details ›
Chain: A
Length: 335 amino acids
Theoretical weight: 38.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14680 (Residues: 3-330; Coverage: 50%)
Gene names: KIAA0175, MELK
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 57.37Å b: 67.81Å c: 103.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.178 0.208
Expression system: Escherichia coli BL21(DE3)