X-ray diffraction
1.2Å resolution

Macrolide 2'-phosphotransferase type I - complex with guanosine and azithromycin


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
APH domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 33.27 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q47396 (Residues: 1-301; Coverage: 100%)
Gene names: ABT96_005409, ABT96_005656, AKG29_00750, AM340_05565, AZ95_0038, B6R12_004237, B6R12_005520, B6R15_004958, B6R15_005532, B9T59_28660, BANRA_05008, BANRA_05393, BE963_00520, BH692_25840, BJI68_09330, BJJ90_27660, BK272_26510, BK292_28790, BK373_25655, BK375_28440, BMC34_003795, BMC34_005393, BON83_00200, BON86_00135, BON94_01620, BON96_04030, BON98_24665, BVL39_07775, BVL39_26555, C5Y87_27150, CBT22_004983, CBT22_005559, CDL36_28340, CLG78_005221, CLG78_005669, CQP61_00510, CWS33_26285, D0X26_00065, D0X26_28390, D3O91_28150, D4U49_26725, D4U49_28850, DS732_30505, E5P52_23260, EHH55_26515, EI021_26230, EI041_22580, EIA13_26870, EIZ93_26315, ELT17_24440, ELT17_26465, ELT29_23950, ELT31_24935, ELT31_26145, ELT33_25215, ELT72_25060, ELV08_25535, ELV15_24060, ELV22_23870, ELV22_25960, ELV24_24180, ELV24_25785, ELV28_26235, ELV28_27675, ELV28_29590, ELX56_25505, ELX56_25985, ELX68_23715, ELX68_25540, ELX76_26525, ELX76_27685, ELX79_23940, ELX79_27660, ELX83_25990, ELX83_26675, ELX96_23275, ELX96_27940, ELY23_24430, ELY23_26140, ELY32_25815, ELY32_27370, ELY41_23030, ELY41_28165, ELY50_24960, ELY50_26940, ERS085366_04054, ETN48_p0083, EXX13_27015, Esc0902E_48450, F3N40_24945, F3N40_27760, F6U69_26325, F6U69_27685, FTV93_29750, G3565_27960, G6P89_27005, GLW94_27645, GLW94_28175, GRC73_23725, GRC73_24610, HJU54_005032, HJU54_005224, HL601_25845, HL601_27150, HLU10_23940, HLU10_24670, HLV18_23945, HLV18_24690, HLZ20_25760, HLZ20_27510, HMJ82_28325, HMJ82_29140, HMT08_29160, HMV95_24745, HMV95_26330, HNC36_28330, HNC36_29450, HNC38_25510, HNC38_27325, HNC52_26375, HNC52_28020, HNC59_25665, HNC59_29535, HNC99_25610, HNC99_29535, HND12_28585, HND12_30625, HND24_26420, HND24_27740, HNV65_26155, HNV65_27160, HNV94_25600, HNV94_28025, HNY50_24480, HNY50_26465, HPE39_25975, HVX16_27920, RCS28_PI0046, RCS44_P0046, RCS51_P0074, RCS55TR727_P0021, RCS57_p0100, RCS65_P0021, RCS78_P0037, RCS79_P0002, SAMEA4362930_00091, SAMEA4370330_00104, SAMEA4370365_00007, SAMEA4370473_00005, THOESC010_P11200, TUM18780_18910, TUM18780_46330, mph(A), mph2, mphA, orf00017, pCTXM123_C0996_11
Sequence domains: Phosphotransferase enzyme family

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P3221
Unit cell:
a: 45.31Å b: 45.31Å c: 247.42Å
α: 90° β: 90° γ: 120°
R R work R free
0.161 0.161 0.163
Expression system: Escherichia coli BL21(DE3)