› 5ifh

X-ray diffraction
2.29Å resolution

Crystal structure of the BCR Fab fragment from subset #2 case P11475

Released:
DOI: 10.2210/pdb5ifh/pdb
PDB 5ifh coloured by chain and viewed from the front.
PDB 5ifh coloured by chain and viewed from the side.
PDB 5ifh coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.
Minici C, Gounari M, Übelhart R, Scarfò L, Dühren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M
Nat Commun 8 15746 (2017)
PMID: 28598442

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heavy chain of the Fab fragment from BCR derived from the P11475 CLL clone Chain: H
Molecule details ›
Chain: H
Length: 221 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Light chain of the Fab fragment from BCR derived from the P11475 CLL clone Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P41
Unit cell:
a: 65.872Å b: 65.872Å c: 111.233Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.18 0.209
Expression system: Homo sapiens

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Citations

17 review citations

Biological and Clinical Insight from Analysis of the Tumor B-Cell Receptor Structure and Function in Chronic Lymphocytic Leukemia.
Forconi et al. (2022)
16 more

4 mentions without citation

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.
Minici et al. (2017)
3 more