PDBe 5i96

X-ray diffraction
1.55Å resolution

Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with AG-221 (Enasidenib) Inhibitor.


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Isocitrate dehydrogenase [NADP], mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 458 amino acids
Theoretical weight: 51.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Best match: P48735 (Residues: 1-452)
Gene name: IDH2

Ligands and Environments

Cofactor: Ligand NDP 2 x NDP

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 58.368Å b: 120.348Å c: 124.734Å
α: 90° β: 90° γ: 90°
R R work R free
0.165 0.163 0.199
Expression system: Spodoptera frugiperda