5i35

X-ray diffraction
2.3Å resolution

Structure of the Human mitochondrial kinase COQ8A R611K with AMPPNP (Cerebellar Ataxia and Ubiquinone Deficiency Through Loss of Unorthodox Kinase Activity)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Atypical kinase COQ8A, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NI60 (Residues: 256-647; Coverage: 61%)
  • Best match: Q8NI60-4 (Residues: 1-368)
Gene names: ADCK3, CABC1, COQ8A, PP265
Sequence domains: ABC1 atypical kinase-like domain

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 150.05Å b: 59.12Å c: 51Å
α: 90° β: 97.69° γ: 90°
R-values:
R R work R free
0.19 0.183 0.259
Expression system: Escherichia coli