X-ray diffraction
2.3Å resolution

Structure of the Human mitochondrial kinase COQ8A R611K with AMPPNP (Cerebellar Ataxia and Ubiquinone Deficiency Through Loss of Unorthodox Kinase Activity)


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Atypical kinase COQ8A, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8NI60 (Residues: 256-647; Coverage: 61%)
  • Best match: Q8NI60-4 (Residues: 1-368)
Gene names: ADCK3, CABC1, COQ8A, PP265
Sequence domains: ABC1 atypical kinase-like domain

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 150.05Å b: 59.12Å c: 51Å
α: 90° β: 97.69° γ: 90°
R R work R free
0.19 0.183 0.259
Expression system: Escherichia coli