› 5i17

X-ray diffraction
3.3Å resolution

CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1-69/IGKV3-20

Released:
DOI: 10.2210/pdb5i17/pdb
PDB 5i17 coloured by chain and viewed from the front.
PDB 5i17 coloured by chain and viewed from the side.
PDB 5i17 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural diversity in a human antibody germline library.
Teplyakov A, Obmolova G, Malia TJ, Luo J, Muzammil S, Sweet R, Almagro JC, Gilliland GL
MAbs 0 (2016)
PMID: 27210805

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
FAB LIGHT CHAIN Chains: A, L
Molecule details ›
Chains: A, L
Length: 215 amino acids
Theoretical weight: 23.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
FAB HEAVY CHAIN Chains: B, H
Molecule details ›
Chains: B, H
Length: 228 amino acids
Theoretical weight: 24.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P422
Unit cell:
a: 152.48Å b: 152.48Å c: 123.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.247
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Nanobody: A Small Antibody with Big Implications for Tumor Therapeutic Strategy.
Sun et al. (2021)
6 more

7 mentions without citation

Impact of the Protein Data Bank on antineoplastic approvals.
Westbrook et al. (2020)
6 more