› 5i04

X-ray diffraction
2.42Å resolution

Crystal structure of the orphan region of human endoglin/CD105

Released:
DOI: 10.2210/pdb5i04/pdb
PDB 5i04 coloured by chain and viewed from the front.
PDB 5i04 coloured by chain and viewed from the side.
PDB 5i04 coloured by chain and viewed from the top.
Source organisms:
Primary publication:
Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Saito T, Bokhove M, Croci R, Zamora-Caballero S, Han L, Letarte M, de Sanctis D, Jovine L
Cell Rep 19 1917-1928 (2017)
PMID: 28564608

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Endoglin; Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 692 amino acids
Theoretical weight: 75.25 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P0AEX9 (Residues: 27-393; Coverage: 99%)
  • Canonical: P17813 (Residues: 26-337; Coverage: 49%)
Gene names: END, ENG, JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand PGE 3 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P65
Unit cell:
a: 114.15Å b: 114.15Å c: 120.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.263
Expression system: Homo sapiens

Quick links

Citations

20 review citations

TGF-β superfamily co-receptors in cancer.
Pawlak et al. (2022)
19 more

2 mentions without citation

Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family.
Kim et al. (2019)
1 more