PDBe 5hzw

X-ray diffraction
4.45Å resolution

Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Endoglin; Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 691 amino acids
Theoretical weight: 75.14 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P17813 (Residues: 26-337; Coverage: 49%)
  • Canonical: P0AEX9 (Residues: 27-393; Coverage: 99%)
  • nullnull
Gene names: END, ENG, JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein
Growth/differentiation factor 2 Chain: B
Molecule details ›
Chain: B
Length: 110 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UK05 (Residues: 320-429; Coverage: 27%)
Gene names: BMP9, GDF2
Sequence domains: Transforming growth factor beta like domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P64
Unit cell:
a: 211.245Å b: 211.245Å c: 53.164Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.289 0.286 0.318
Expression system: Homo sapiens