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Crystal structure of LIMK1 mutant D460N in complex with full-length cofilin-1

X-ray diffraction
3.5Å resolution
PDB entry 5hvk coloured by chain, front view.
PDB entry 5hvk coloured by chain, side view.
PDB entry 5hvk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: LIM domain kinase 1 and Cofilin-1
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Multimeric state: hetero dimer
Accessible surface area: 22596.38 Å2
Buried surface area: 2854.53 Å2
Dissociation area: 982.42 Å2
Dissociation energy (ΔGdiss): 7.33 kcal/mol
Dissociation entropy (TΔSdiss): 12.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149995
Assembly 2
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Assembly Name: LIM domain kinase 1 and Cofilin-1
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Multimeric state: hetero dimer
Accessible surface area: 22473.39 Å2
Buried surface area: 2779.49 Å2
Dissociation area: 925.61 Å2
Dissociation energy (ΔGdiss): 2.54 kcal/mol
Dissociation entropy (TΔSdiss): 12.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149995

Macromolecules

LIM domain kinase 1
Chains: A, C
Length: 315 amino acids
Theoretical weight: 36.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53667 (Residues: 329-638; Coverage: 48%)
Gene names: LIMK, LIMK1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
LIM domain kinase 1 in PDB entry 5hvk, assembly 1, front view.
LIM domain kinase 1 in PDB entry 5hvk, assembly 1, side view.
LIM domain kinase 1 in PDB entry 5hvk, assembly 1, top view.
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Cofilin-1
Chain: B
Length: 165 amino acids
Theoretical weight: 18.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23528 (Residues: 2-166; Coverage: 99%)
Gene names: CFL, CFL1
Pfam: Cofilin/tropomyosin-type actin-binding protein
InterPro:
CATH: Severin
Cofilin-1 in PDB entry 5hvk, assembly 1, front view.
Cofilin-1 in PDB entry 5hvk, assembly 1, side view.
Cofilin-1 in PDB entry 5hvk, assembly 1, top view.
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Cofilin-1
Chain: D
Length: 165 amino acids
Theoretical weight: 18.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23528 (Residues: 2-166; Coverage: 99%)
Gene names: CFL, CFL1
Pfam: Cofilin/tropomyosin-type actin-binding protein
InterPro:
CATH: Severin
Cofilin-1 in PDB entry 5hvk, assembly 2, front view.
Cofilin-1 in PDB entry 5hvk, assembly 2, side view.
Cofilin-1 in PDB entry 5hvk, assembly 2, top view.
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