› 5hv1

X-ray diffraction
3.1Å resolution

Rifampin phosphotransferase in complex with AMPPNP and rifampin from Listeria monocytogenes

Released:
DOI: 10.2210/pdb5hv1/pdb
PDB entry 5hv1 coloured by chain, front view.
PDB entry 5hv1 coloured by chain, side view.
PDB entry 5hv1 coloured by chain, top view.
Source organism: Listeria monocytogenes
Primary publication:
Structural basis of rifampin inactivation by rifampin phosphotransferase.
Qi X, Lin W, Ma M, Wang C, He Y, He N, Gao J, Zhou H, Xiao Y, Wang Y, Zhang P
Proc Natl Acad Sci U S A 113 3803-8 (2016)
PMID: 27001859

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoenolpyruvate synthase Chain: A
Molecule details ›
Chain: A
Length: 883 amino acids
Theoretical weight: 98.81 KDa
Source organism: Listeria monocytogenes
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand ANP 1 x ANP
Ligand RFP 1 x RFP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P6522
Unit cell:
a: 151.09Å b: 151.09Å c: 191.648Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.253 0.25 0.286
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification.
El-Khoury et al. (2022)
9 other articles

2 mentions without citation

Structural basis of rifampin inactivation by rifampin phosphotransferase.
Qi et al. (2016)
1 more