› › Structure analysis

BACE1 in complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5-oxo-4-phenylimidazolidin-2-iminium

X-ray diffraction
1.83Å resolution
PDB entry 5hu0 coloured by chain, front view.
PDB entry 5hu0 coloured by chain, side view.
PDB entry 5hu0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-secretase 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-157541
Assembly 2
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Assembly Name: Beta-secretase 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-157541

Macromolecules

Beta-secretase 1
Chains: A, B
Length: 412 amino acids
Theoretical weight: 45.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56817 (Residues: 43-454; Coverage: 86%)
Gene names: BACE, BACE1, KIAA1149
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
Beta-secretase 1 in PDB entry 5hu0, assembly 1, front view.
Beta-secretase 1 in PDB entry 5hu0, assembly 1, side view.
Beta-secretase 1 in PDB entry 5hu0, assembly 1, top view.
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