EC 1.5.1.3: Dihydrofolate reductase
Reaction catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
Systematic name:
5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
- 7,8-dihydrofolate reductase
- DHFR
- Dihydrofolate reductase:thymidylate synthase
- Dihydrofolic acid reductase
- Dihydrofolic reductase
- Folic acid reductase
- Folic reductase
- NADPH-dihydrofolate reductase
- Pteridine reductase:dihydrofolate reductase
- Tetrahydrofolate dehydrogenase
- Thymidylate synthetase-dihydrofolate reductase
GO terms
Biochemical function:
Biological process:
- regulation of removal of superoxide radicals
- positive regulation of nitric-oxide synthase activity
- folic acid metabolic process
- tetrahydrofolate biosynthetic process
- tetrahydrofolate metabolic process
- dihydrofolate metabolic process
- response to methotrexate
- axon regeneration
- negative regulation of translation
- one-carbon metabolic process
- tetrahydrobiopterin biosynthetic process
- glycine biosynthetic process
Protein family (Pfam)
InterPro annotations
CATH domain