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Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site

X-ray diffraction
3.091Å resolution
PDB entry 5hp3 coloured by chain, front view.
PDB entry 5hp3 coloured by chain, side view.
PDB entry 5hp3 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Double-stranded RNA-specific editase 1 and RNA
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Multimeric state: hetero tetramer
Accessible surface area: 38269.98 Å2
Buried surface area: 9568.01 Å2
Dissociation area: 1,201.22 Å2
Dissociation energy (ΔGdiss): 2.7 kcal/mol
Dissociation entropy (TΔSdiss): 14.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160294

Macromolecules

Double-stranded RNA-specific editase 1
Chains: A, D
Length: 403 amino acids
Theoretical weight: 45.01 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P78563 (Residues: 299-741; Coverage: 54%)
Gene names: ADAR2, ADARB1, DRADA2, RED1
Pfam: Adenosine-deaminase (editase) domain
InterPro:
Double-stranded RNA-specific editase 1 in PDB entry 5hp3, assembly 1, front view.
Double-stranded RNA-specific editase 1 in PDB entry 5hp3, assembly 1, side view.
Double-stranded RNA-specific editase 1 in PDB entry 5hp3, assembly 1, top view.
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RNA chain B
Name: RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3')
Representative chains: B
Source organism: Saccharomyces cerevisiae [4932]
Expression system: Not provided
Length: 23 nucleotides
Theoretical weight: 7.23 KDa
RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3') in PDB entry 5hp3, assembly 1, front view.
RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3') in PDB entry 5hp3, assembly 1, side view.
RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3') in PDB entry 5hp3, assembly 1, top view.
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RNA chain C
Name: RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3')
Representative chains: C
Source organism: Saccharomyces cerevisiae [4932]
Expression system: Not provided
Length: 23 nucleotides
Theoretical weight: 7.49 KDa
RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3') in PDB entry 5hp3, assembly 1, front view.
RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3') in PDB entry 5hp3, assembly 1, side view.
RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3') in PDB entry 5hp3, assembly 1, top view.
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