› 5hn7

X-ray diffraction
2.15Å resolution

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1158

Released:
DOI: 10.2210/pdb5hn7/pdb
PDB 5hn7 coloured by chain and viewed from the front.
PDB 5hn7 coloured by chain and viewed from the side.
PDB 5hn7 coloured by chain and viewed from the top.
Source organism: Plasmodium vivax Sal-1
Primary publication:
Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
G Ricci C, Liu YL, Zhang Y, Wang Y, Zhu W, Oldfield E, McCammon JA
Biochemistry (2016)
PMID: 27564465

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase, putative Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 375 amino acids
Theoretical weight: 43.78 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5K4U6 (Residues: 1-375; Coverage: 100%)
Gene name: PVX_092040
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:
Ligand 04M 8 x 04M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 107.783Å b: 108.378Å c: 140.041Å
α: 90° β: 90.43° γ: 90°
R-values:
R R work R free
0.2 0.198 0.249
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

MalDA, Accelerating Malaria Drug Discovery.
Yang et al. (2021)
2 more

1 mention without citation

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
G Ricci et al. (2016)