X-ray diffraction
2.15Å resolution

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1158


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Farnesyl pyrophosphate synthase, putative Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 375 amino acids
Theoretical weight: 43.78 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli BL21(DE3)
  • Canonical: A5K4U6 (Residues: 1-375; Coverage: 100%)
Gene name: PVX_092040
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 107.783Å b: 108.378Å c: 140.041Å
α: 90° β: 90.43° γ: 90°
R R work R free
0.2 0.198 0.249
Expression system: Escherichia coli BL21(DE3)