› 5hmp

X-ray diffraction
2.4Å resolution

Myosin Vc pre-powerstroke state

Released:
DOI: 10.2210/pdb5hmp/pdb
PDB entry 5hmp coloured by chain, front view.
PDB entry 5hmp coloured by chain, side view.
PDB entry 5hmp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The myosin X motor is optimized for movement on actin bundles.
Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, Sweeney HL, Houdusse A
Nat Commun 7 12456 (2016)
PMID: 27580874

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192522 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-Vc Chains: A, B
Molecule details ›
Chains: A, B
Length: 750 amino acids
Theoretical weight: 86.36 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9NQX4 (Residues: 5-754; Coverage: 43%)
Gene name: MYO5C
Sequence domains: Myosin head (motor domain)

Ligands and Environments

5 bound ligands:
Ligand MG 2 x MG
Ligand VO4 2 x VO4
Ligand ADP 2 x ADP
Ligand EDO 3 x EDO
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 103.78Å b: 66.74Å c: 131.26Å
α: 90° β: 104.45° γ: 90°
R-values:
R R work R free
0.206 0.205 0.226
Expression system: unidentified baculovirus

Quick links

Citations

7 review citations

MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.
Weck et al. (2017)
6 more

4 mentions without citation

Interaction of Vanadium Complexes with Proteins: Revisiting the Reported Structures in the Protein Data Bank (PDB) since 2015.
Santos et al. (2023)
3 more