5hlz

X-ray diffraction
2.85Å resolution

Structure of Pro-Activin A Complex at 2.85 A resolution

Released:
Source organism: Homo sapiens
Primary publication:
Structure and activation of pro-activin A.
Nat Commun 7 12052 (2016)
PMID: 27373274

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inhibin beta A chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 270 amino acids
Theoretical weight: 30.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08476 (Residues: 30-305; Coverage: 62%)
Gene name: INHBA
Sequence domains: TGF-beta propeptide
Inhibin beta A chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08476 (Residues: 311-426; Coverage: 29%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P31
Unit cell:
a: 47.227Å b: 47.227Å c: 445.425Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.274
Expression system: Escherichia coli BL21(DE3)