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Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form)

X-ray diffraction
1.8Å resolution
PDB entry 5hky coloured by chain, front view.
PDB entry 5hky coloured by chain, side view.
PDB entry 5hky coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein sprouty homolog 2 and E3 ubiquitin-protein ligase CBL
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Multimeric state: hetero dimer
Accessible surface area: 15020.73 Å2
Buried surface area: 2973.19 Å2
Dissociation area: 1,113.88 Å2
Dissociation energy (ΔGdiss): 13.34 kcal/mol
Dissociation entropy (TΔSdiss): 9.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129015

Macromolecules

E3 ubiquitin-protein ligase CBL
Chain: A
Length: 308 amino acids
Theoretical weight: 35.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22681 (Residues: 47-351; Coverage: 34%)
Gene names: CBL, CBL2, RNF55
Pfam:
InterPro:
CATH:
E3 ubiquitin-protein ligase CBL in PDB entry 5hky, assembly 1, front view.
E3 ubiquitin-protein ligase CBL in PDB entry 5hky, assembly 1, side view.
E3 ubiquitin-protein ligase CBL in PDB entry 5hky, assembly 1, top view.
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Protein sprouty homolog 2
Chain: B
Length: 26 amino acids
Theoretical weight: 2.99 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43597 (Residues: 35-60; Coverage: 8%)
Gene name: SPRY2
Protein sprouty homolog 2 in PDB entry 5hky, assembly 1, front view.
Protein sprouty homolog 2 in PDB entry 5hky, assembly 1, side view.
Protein sprouty homolog 2 in PDB entry 5hky, assembly 1, top view.
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