Structure analysis

Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine

X-ray diffraction
2.76Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 36100 Å2
Buried surface area: 2200 Å2
Dissociation area: 300 Å2
Dissociation energy (ΔGdiss): -5 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 922 amino acids
Theoretical weight: 102.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52789 (Residues: 17-916; Coverage: 98%)
Gene name: HK2
Pfam:
InterPro:
CATH:

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