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Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine

X-ray diffraction
2.76Å resolution
PDB 5hg1 coloured by chain and viewed from the front.
PDB 5hg1 coloured by chain and viewed from the side.
PDB 5hg1 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 36100 Å2
Buried surface area: 2200 Å2
Dissociation area: 300 Å2
Dissociation energy (ΔGdiss): -5 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1

Macromolecules

Hexokinase-2
Chain: A
Length: 922 amino acids
Theoretical weight: 102.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52789 (Residues: 17-916; Coverage: 98%)
Gene name: HK2
Pfam:
InterPro:
CATH:
PDB 5hg1 contains 1 copy of Hexokinase-2 in assembly 1. This protein is highlighted and viewed from the front.
PDB 5hg1 contains 1 copy of Hexokinase-2 in assembly 1. This protein is highlighted and viewed from the side.
PDB 5hg1 contains 1 copy of Hexokinase-2 in assembly 1. This protein is highlighted and viewed from the top.
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