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The third PDZ domain from the synaptic protein PSD-95 (H372A mutant) in complex with a C-terminal peptide derived from CRIPT

X-ray diffraction
1.616Å resolution
PDB entry 5hfb coloured by chain, front view.
PDB entry 5hfb coloured by chain, side view.
PDB entry 5hfb coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cysteine-rich PDZ-binding protein and Disks large homolog 4
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Multimeric state: hetero dimer
Accessible surface area: 6756.79 Å2
Buried surface area: 855.73 Å2
Dissociation area: 427.86 Å2
Dissociation energy (ΔGdiss): 0.37 kcal/mol
Dissociation entropy (TΔSdiss): 6.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151888

Macromolecules

Disks large homolog 4
Chain: A
Length: 119 amino acids
Theoretical weight: 12.67 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31016 (Residues: 302-402; Coverage: 14%)
Gene names: Dlg4, Dlgh4, Psd95
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
Disks large homolog 4 in PDB entry 5hfb, assembly 1, front view.
Disks large homolog 4 in PDB entry 5hfb, assembly 1, side view.
Disks large homolog 4 in PDB entry 5hfb, assembly 1, top view.
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Cysteine-rich PDZ-binding protein
Chain: B
Length: 9 amino acids
Theoretical weight: 1.07 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: Q792Q4 (Residues: 93-101; Coverage: 9%)
Gene name: Cript
Cysteine-rich PDZ-binding protein in PDB entry 5hfb, assembly 1, front view.
Cysteine-rich PDZ-binding protein in PDB entry 5hfb, assembly 1, side view.
Cysteine-rich PDZ-binding protein in PDB entry 5hfb, assembly 1, top view.
Molecule details ›

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