X-ray diffraction
2.73Å resolution

Crystal Structure of Human Hexokinase 2 with cmpd 30, a 2-amino-6-benzenesulfonamide glucosamine


Function and Biology Details

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hexokinase-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 923 amino acids
Theoretical weight: 103.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P52789 (Residues: 17-917; Coverage: 98%)
Gene name: HK2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P21
Unit cell:
a: 66.032Å b: 154.893Å c: 114.825Å
α: 90° β: 96.34° γ: 90°
R R work R free
0.193 0.19 0.252
Expression system: Escherichia coli