5hde

X-ray diffraction
1.62Å resolution

Crystal Structure of PTPN12 Catalytic Domain

Released:
Source organism: Homo sapiens
Entry authors: Dong H, Li S, Shi J

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 12 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 36.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q05209 (Residues: 1-301; Coverage: 39%)
Gene name: PTPN12
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2
Unit cell:
a: 136.01Å b: 40.967Å c: 75.686Å
α: 90° β: 116.63° γ: 90°
R-values:
R R work R free
0.167 0.164 0.213
Expression system: Escherichia coli BL21(DE3)