X-ray diffraction
2.24Å resolution

Crystal structure of PTK6 Kinase Domain complexed with Dasatinib


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein-tyrosine kinase 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 267 amino acids
Theoretical weight: 30.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q13882 (Residues: 185-446; Coverage: 58%)
Gene names: BRK, PTK6
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 49.881Å b: 77.018Å c: 87.413Å
α: 81.36° β: 75.76° γ: 74.92°
R R work R free
0.208 0.206 0.26
Expression system: Spodoptera frugiperda