› 5gxp

X-ray diffraction
2.8Å resolution

Cationic Trypsin With GOL/PGE as Dimer at pH 4.6

Released:
DOI: 10.2210/pdb5gxp/pdb
PDB 5gxp coloured by chain and viewed from the front.
PDB 5gxp coloured by chain and viewed from the side.
PDB 5gxp coloured by chain and viewed from the top.
Source organism: Bos taurus
Entry authors: Manohar R, Gunasekaran K

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

3 bound ligands:
Ligand CA 12 x CA
Ligand PGE 2 x PGE
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P212121
Unit cell:
a: 60.84Å b: 102.59Å c: 115.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.279 0.275 0.309
Expression system: Not provided

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