Structure analysis

Crystal structure of 2C helicase from enterovirus 71 (EV71) bound with ATPgammaS

X-ray diffraction
2.803Å resolution
Source organism: Enterovirus
Assemblies composition:
homo tetramer
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: homo tetramer
Accessible surface area: 40600 Å2
Buried surface area: 6400 Å2
Dissociation area: 1,400 Å2
Dissociation energy (ΔGdiss): -8 kcal/mol
Dissociation entropy (TΔSdiss): 26 kcal/mol
Interface energy (ΔGint): -208 kcal/mol
Symmetry number: 1
Assembly 2 (preferred)
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Multimeric state: monomeric
Accessible surface area: 11200 Å2
Buried surface area: 700 Å2
Dissociation area: 300 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -42 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D, E, F
Length: 214 amino acids
Theoretical weight: 23.54 KDa
Source organism: Enterovirus
Expression system: Escherichia coli
UniProt:
  • Canonical: B9VUU3 (Residues: 1227-1440; Coverage: 10%)
Pfam: RNA helicase
InterPro:

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