5gqq

X-ray diffraction
2.2Å resolution

Structure of ALG-2/HEBP2 Complex

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heme-binding protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 178 amino acids
Theoretical weight: 20.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q9Y5Z4 (Residues: 20-197; Coverage: 87%)
Gene names: C6orf34, HEBP2, SOUL
Sequence domains: SOUL heme-binding protein
Structure domains: Regulatory factor, effector binding domain
Programmed cell death protein 6 Chains: C, D
Molecule details ›
Chains: C, D
Length: 170 amino acids
Theoretical weight: 19.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: O75340 (Residues: 24-191; Coverage: 88%)
Gene names: ALG2, PDCD6
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P1
Unit cell:
a: 47.279Å b: 78.124Å c: 87.171Å
α: 113.71° β: 105.64° γ: 93.95°
R-values:
R R work R free
0.196 0.194 0.225
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'