5glh

X-ray diffraction
2.8Å resolution

Human endothelin receptor type-B in complex with ET-1

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Endolysin; Endothelin receptor type B Chain: A
Molecule details ›
Chain: A
Length: 498 amino acids
Theoretical weight: 55.96 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
  • Canonical: P24530 (Residues: 65-303, 311-407; Coverage: 81%)
Gene names: E, EDNRB, ETRB
Sequence domains:
Endothelin-1 Chain: B
Molecule details ›
Chain: B
Length: 21 amino acids
Theoretical weight: 2.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05305 (Residues: 53-73; Coverage: 11%)
Gene name: EDN1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2221
Unit cell:
a: 72.97Å b: 172.97Å c: 109.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.234 0.277
Expression systems:
  • Spodoptera frugiperda
  • Not provided