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Electron Microscopy
3.9Å resolution

Structure of the mammalian voltage-gated calcium channel Cav1.1 complex for ClassII map

Released:
Source organism: Oryctolagus cuniculus
Related structures: EMD-9515

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (8 distinct):
Voltage-dependent L-type calcium channel subunit alpha-1S Chain: A
Molecule details ›
Chain: A
Length: 1873 amino acids
Theoretical weight: 212.24 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P07293 (Residues: 1-1873; Coverage: 100%)
Gene names: CACH1, CACNA1S, CACNL1A3
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 106 amino acids
Theoretical weight: 11.97 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19517 (Residues: 80-174; Coverage: 18%)
Gene names: CACNB1, CACNLB1
Structure domains: SH3 Domains
Voltage-dependent L-type calcium channel subunit beta-1 Chain: C
Molecule details ›
Chain: C
Length: 199 amino acids
Theoretical weight: 22.36 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19517 (Residues: 265-463; Coverage: 38%)
Gene names: CACNB1, CACNLB1
Sequence domains: Guanylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Voltage-dependent calcium channel gamma-1 subunit Chain: E
Molecule details ›
Chain: E
Length: 222 amino acids
Theoretical weight: 25.08 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P19518 (Residues: 1-222; Coverage: 100%)
Gene names: CACNG1, CACNLG
Sequence domains: PMP-22/EMP/MP20/Claudin tight junction
Structure domains: Butyryl-CoA Dehydrogenase, subunit A; domain 3
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: F
Molecule details ›
Chain: F
Length: 1106 amino acids
Theoretical weight: 125.16 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P13806 (Residues: 1-1106; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-9515
Expression system: Escherichia coli