PDBe 5gje

Electron Microscopy
21Å resolution

Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Low-density lipoprotein receptor-related protein 6 Chain: A
Molecule details ›
Chain: A
Length: 611 amino acids
Theoretical weight: 69.03 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O75581 (Residues: 20-630; Coverage: 38%)
Gene name: LRP6
Sequence domains:
Low-density lipoprotein receptor-related protein 6 Chain: B
Molecule details ›
Chain: B
Length: 616 amino acids
Theoretical weight: 69.81 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75581 (Residues: 631-1246; Coverage: 39%)
Gene name: LRP6
Sequence domains:
Dickkopf-related protein 1 Chain: C
Molecule details ›
Chain: C
Length: 85 amino acids
Theoretical weight: 9.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O94907 (Residues: 182-266; Coverage: 36%)
Gene names: DKK1, UNQ492/PRO1008

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 21Å
Relevant EMDB volumes: EMD-9501
Expression systems:
  • Cricetulus griseus
  • Spodoptera frugiperda