› › Function and Biology

Crystal structure of JmjC domain of human histone demethylase UTY in complex with D-2-hydroxyglutarate

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 1.14.11.68: [Histone H3]-trimethyl-L-lysine(27) demethylase

Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(27) + succinate + formaldehyde + CO(2)
Systematic name:
[Histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27),2-oxoglutarate:oxygen oxidoreductase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF21326
Domain description: KDM6, GATA-like
Occurring in:
  1. Histone demethylase UTY
The deposited structure of PDB entry 5fym contains 2 copies of Pfam domain PF21326 (KDM6, GATA-like) in Histone demethylase UTY. Showing 1 copy in chain B.

PF21322
Domain description: Lysine-specific demethylase 6/UTY, C-terminal helical domain
Occurring in:
  1. Histone demethylase UTY
The deposited structure of PDB entry 5fym contains 2 copies of Pfam domain PF21322 (Lysine-specific demethylase 6/UTY, C-terminal helical domain) in Histone demethylase UTY. Showing 1 copy in chain B.

PF02373
Domain description: JmjC domain, hydroxylase
Occurring in:
  1. Histone demethylase UTY
The deposited structure of PDB entry 5fym contains 2 copies of Pfam domain PF02373 (JmjC domain, hydroxylase) in Histone demethylase UTY. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR003347
Domain description: JmjC domain
Occurring in:
  1. Histone demethylase UTY
IPR046941
Domain description: Lysine-specific demethylase 6, GATA-like domain superfamily
Occurring in:
  1. Histone demethylase UTY

Structure domains

CATH CATH domains
1.20.58.1370
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Occurring in:
  1. Histone demethylase UTY
The deposited structure of PDB entry 5fym contains 2 copies of CATH domain 1.20.58.1370 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in Histone demethylase UTY. Showing 1 copy in chain B.
2.10.110.20
Class: Mainly Beta
Architecture: Ribbon
Topology: Cysteine Rich Protein
Homology: Cysteine Rich Protein
Occurring in:
  1. Histone demethylase UTY
The deposited structure of PDB entry 5fym contains 2 copies of CATH domain 2.10.110.20 (Cysteine Rich Protein) in Histone demethylase UTY. Showing 1 copy in chain B.
2.60.120.650
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Cupin
Occurring in:
  1. Histone demethylase UTY
The deposited structure of PDB entry 5fym contains 2 copies of CATH domain 2.60.120.650 (Jelly Rolls) in Histone demethylase UTY. Showing 1 copy in chain B.

Quick links