PDBe 5fym

X-ray diffraction
2Å resolution

Crystal structure of JmjC domain of human histone demethylase UTY in complex with D-2-hydroxyglutarate

Released:
Source organism: Homo sapiens
Entry authors: Nowak R, Krojer T, Johansson C, Gileadi C, Kupinska K, von Delft F, Arrowsmith CH, Bountra C, Edwards A, Oppermann U

Function and Biology Details

Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone demethylase UTY Chains: A, B
Molecule details ›
Chains: A, B
Length: 478 amino acids
Theoretical weight: 55.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14607 (Residues: 878-1347; Coverage: 35%)
Gene names: KDM6C, UTY
Sequence domains: JmjC domain, hydroxylase
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 90.48Å b: 109.34Å c: 117.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.245
Expression system: Spodoptera frugiperda