PDBe 5fww

X-ray diffraction
3.5Å resolution

Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Low-density lipoprotein receptor-related protein 6 Chain: A
Molecule details ›
Chain: A
Length: 619 amino acids
Theoretical weight: 70.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75581 (Residues: 630-1246; Coverage: 39%)
Gene name: LRP6
Sequence domains:
Structure domains: TolB, C-terminal domain
Kremen protein 1 Chain: B
Molecule details ›
Chain: B
Length: 293 amino acids
Theoretical weight: 32.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96MU8 (Residues: 30-322; Coverage: 65%)
Gene names: KREMEN, KREMEN1, KRM1
Sequence domains:
Dickkopf-related protein 1 Chain: C
Molecule details ›
Chain: C
Length: 85 amino acids
Theoretical weight: 9.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94907 (Residues: 182-266; Coverage: 36%)
Gene names: DKK1, UNQ492/PRO1008
Structure domains: Lipase, subunit A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 86.933Å b: 100.08Å c: 270.728Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.323 0.321 0.355
Expression system: Homo sapiens