PDBe 5fwp

Electron Microscopy
7.2Å resolution

Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Heat shock protein HSP 90-beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 727 amino acids
Theoretical weight: 83.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08238 (Residues: 1-724; Coverage: 100%)
Gene names: HSP90AB1, HSP90B, HSPC2, HSPCB
Sequence domains:
Hsp90 co-chaperone Cdc37 Chain: E
Molecule details ›
Chain: E
Length: 378 amino acids
Theoretical weight: 44.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16543 (Residues: 1-378; Coverage: 100%)
Gene names: CDC37, CDC37A
Sequence domains:
Cyclin-dependent kinase 4 Chain: K
Molecule details ›
Chain: K
Length: 310 amino acids
Theoretical weight: 34.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11802 (Residues: 1-303; Coverage: 100%)
Gene name: CDK4
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 7.2Å
Relevant EMDB volumes: EMD-3340
Expression system: Spodoptera frugiperda