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Crystal structure of the cysteine desulfurase CsdA from Escherichia coli at 1.996 Angstroem resolution

Source organism: Escherichia coli K-12
Biochemical function: cysteine desulfurase activity
Biological process: sulfur compound transport
Cellular component: L-cysteine desulfurase complex

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EC 2.8.1.7: Cysteine desulfurase

Reaction catalysed:
(1a) L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
Systematic name:
L-cysteine:acceptor sulfurtransferase
Alternative Name(s):
  • Cysteine desulfurylase
  • IscS
  • NIFS
  • NifS
  • SufS

EC 4.4.1.16: Selenocysteine lyase

Reaction catalysed:
L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor
Systematic name:
L-selenocysteine selenide-lyase (L-alanine-forming)
Alternative Name(s):
  • Selenocysteine beta-lyase
  • Selenocysteine reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00266
Domain description: Aminotransferase class-V
Occurring in:
  1. Cysteine desulfurase CsdA
The deposited structure of PDB entry 5ft4 contains 2 copies of Pfam domain PF00266 (Aminotransferase class-V) in Cysteine desulfurase CsdA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR020578
Domain description: Aminotransferase class-V, pyridoxal-phosphate binding site
Occurring in:
  1. Cysteine desulfurase CsdA
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Cysteine desulfurase CsdA
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Cysteine desulfurase CsdA
IPR010970
Domain description: Cysteine desulfurase, SufS
Occurring in:
  1. Cysteine desulfurase CsdA
IPR000192
Domain description: Aminotransferase class V domain
Occurring in:
  1. Cysteine desulfurase CsdA
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Cysteine desulfurase CsdA
IPR022471
Domain description: Cysteine desulphurase, catalytic subunit, CsdA
Occurring in:
  1. Cysteine desulfurase CsdA

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Cysteine desulfurase CsdA
The deposited structure of PDB entry 5ft4 contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Cysteine desulfurase CsdA. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Cysteine desulfurase CsdA
The deposited structure of PDB entry 5ft4 contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Cysteine desulfurase CsdA. Showing 1 copy in chain A.

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