X-ray diffraction
2.77Å resolution

Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AP-2 complex subunit mu Chain: A
Molecule details ›
Chain: A
Length: 446 amino acids
Theoretical weight: 51.04 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
  • Canonical: P84092 (Residues: 1-236, 237-435; Coverage: 100%)
Gene name: Ap2m1
Sequence domains:
Structure domains: Mu homology domain, subdomain B
Integrin alpha-4 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P13612 (Residues: 1008-1015; Coverage: 1%)
Gene names: CD49D, ITGA4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P64
Unit cell:
a: 125.65Å b: 125.65Å c: 74.41Å
α: 90° β: 90° γ: 120°
R R work R free
0.177 0.174 0.224
Expression systems:
  • Escherichia coli
  • Not provided