5foa

X-ray diffraction
4.19Å resolution

Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C3 beta chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-667; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Complement C3b alpha' chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Gene names: C3, CPAMD1
Sequence domains:
Complement decay-accelerating factor Chains: E, F
Molecule details ›
Chains: E, F
Length: 194 amino acids
Theoretical weight: 21.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08174 (Residues: 97-285; Coverage: 55%)
Gene names: CD55, CR, DAF
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Unit cell:
a: 117.429Å b: 142.378Å c: 323.697Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.271 0.27 0.307
Expression system: Homo sapiens