X-ray diffraction
3.3Å resolution

Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17)


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C3 beta chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
  • Canonical: P01024 (Residues: 23-667; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Structure domains:
Complement C3b alpha' chain Chains: B, E
Complement receptor type 1 Chains: C, F
Molecule details ›
Chains: C, F
Length: 196 amino acids
Theoretical weight: 21.62 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P17927 (Residues: 941-1136; Coverage: 10%)
Gene names: C3BR, CR1
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P1
Unit cell:
a: 104.32Å b: 113.71Å c: 138.52Å
α: 82.74° β: 71.77° γ: 80.95°
R R work R free
0.252 0.25 0.291
Expression system: Komagataella pastoris