5fm3

X-ray diffraction
2.95Å resolution

Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble RET kinase fragment Chain: A
Molecule details ›
Chain: A
Length: 355 amino acids
Theoretical weight: 40.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07949 (Residues: 659-1013; Coverage: 33%)
Gene names: CDHF12, CDHR16, PTC, RET, RET51
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6322
Unit cell:
a: 98.569Å b: 98.569Å c: 146.301Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.199 0.224
Expression system: Spodoptera frugiperda