5fg4

X-ray diffraction
1.65Å resolution

Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe

Released:
Source organism: Homo sapiens
Entry authors: Tallant C, Owen DR, Gerstenberger BS, Savitsky P, Chaikuad A, Fedorov O, Nunez-Alonso G, Filippakopoulos P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Muller S, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Unit cell:
a: 47.802Å b: 60.704Å c: 51.171Å
α: 90° β: 100.43° γ: 90°
R-values:
R R work R free
0.203 0.2 0.254
Expression system: Escherichia coli