X-ray diffraction
2Å resolution

Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1

Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
NPC intracellular cholesterol transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O15118 (Residues: 374-620; Coverage: 20%)
Gene name: NPC1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P6122
Unit cell:
a: 60.006Å b: 60.006Å c: 270.347Å
α: 90° β: 90° γ: 120°
R R work R free
0.184 0.182 0.219
Expression system: Escherichia coli