5eyt

X-ray diffraction
2.36Å resolution

Crystal Structure of Adenylosuccinate Lyase from Schistosoma mansoni in complex with AMP

Released:
Source organism: Schistosoma mansoni
Entry authors: Romanello L, Torini JR, Bird L, Nettleship J, Owens R, Reddivari Y, Brandao-Neto J, Pereira HM

Function and Biology Details

Reaction catalysed:
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylosuccinate lyase Chain: A
Molecule details ›
Chain: A
Length: 497 amino acids
Theoretical weight: 56.57 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli
UniProt:
  • Canonical: G4VQX9 (Residues: 1-480; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I222
Unit cell:
a: 70.466Å b: 73.114Å c: 180.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.231
Expression system: Escherichia coli