› 5euz

X-ray diffraction
2.4Å resolution

Rat prestin STAS domain in complex with iodide

Released:
DOI: 10.2210/pdb5euz/pdb
PDB entry 5euz coloured by chain, front view.
PDB entry 5euz coloured by chain, side view.
PDB entry 5euz coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The STAS domain of mammalian SLC26A5 prestin harbours an anion-binding site.
Lolli G, Pasqualetto E, Costanzi E, Bonetto G, Battistutta R
Biochem J 473 365-70 (2016)
PMID: 26635354

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190152 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prestin Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 15.81 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9EPH0 (Residues: 505-563, 637-718; Coverage: 19%)
Gene names: Pres, Slc26a5
Sequence domains: STAS domain
Structure domains: STAS domain

Ligands and Environments

4 bound ligands:
Ligand IOD 4 x IOD
Ligand EDO 5 x EDO
Ligand PGE 1 x PGE
Ligand PEG 2 x PEG
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P3121
Unit cell:
a: 61.911Å b: 61.911Å c: 66.49Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.188 0.221
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Chansporter complexes in cell signaling.
Abbott GW. (2017)
1 more