› 5enn

X-ray diffraction
2.7Å resolution

The crystal structure of Human VPS34 in complex with a selective and potent inhibitor

Released:
DOI: 10.2210/pdb5enn/pdb
PDB entry 5enn coloured by chain, front view.
PDB entry 5enn coloured by chain, side view.
PDB entry 5enn coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Kearney EP

Function and Biology Details

Reaction catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185509 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase catalytic subunit type 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 625 amino acids
Theoretical weight: 71.85 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q8NEB9 (Residues: 293-887; Coverage: 67%)
Gene names: PIK3C3, VPS34
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 5QS 2 x 5QS
Ligand NA 2 x NA
Ligand GOL 1 x GOL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 113.726Å b: 114.481Å c: 143.903Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.201
Expression system: unidentified baculovirus

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