X-ray diffraction
1.82Å resolution

Human mitochondrial tryptophanyl-tRNA synthetase bound by indolmycin and Mn*ATP.

Source organism: Homo sapiens
Entry authors: Williams TL, Carter Jr CW

Function and Biology Details

Reaction catalysed:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Tryptophan--tRNA ligase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 343 amino acids
Theoretical weight: 38.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9UGM6 (Residues: 18-360; Coverage: 95%)
Gene name: WARS2
Sequence domains: tRNA synthetases class I (W and Y)
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 58.289Å b: 78.087Å c: 153.996Å
α: 90° β: 96.55° γ: 90°
R R work R free
0.172 0.17 0.207
Expression system: Escherichia coli