PDBe 5ek7

X-ray diffraction
1.9Å resolution

Structure of the autoinhibited Epha2 JMS-KD

Released:
Source organism: Homo sapiens
Entry authors: Wei Q, Zheng J

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 308 amino acids
Theoretical weight: 35.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29317 (Residues: 583-876; Coverage: 31%)
Gene names: ECK, EPHA2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 63.475Å b: 75.242Å c: 80.483Å
α: 90° β: 112.67° γ: 90°
R-values:
R R work R free
0.172 0.171 0.205
Expression system: Escherichia coli