5ebe

X-ray diffraction
3Å resolution

Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with 5' CMP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acid sphingomyelinase-like phosphodiesterase 3a Chain: A
Molecule details ›
Chain: A
Length: 418 amino acids
Theoretical weight: 47.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92484 (Residues: 33-450; Coverage: 97%)
Gene names: ASML3A, SMPDL3A
Sequence domains: Calcineurin-like phosphoesterase
Acid sphingomyelinase-like phosphodiesterase 3a Chains: B, C
Molecule details ›
Chains: B, C
Length: 415 amino acids
Theoretical weight: 47.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92484 (Residues: 33-447; Coverage: 96%)
Gene names: ASML3A, SMPDL3A
Sequence domains: Calcineurin-like phosphoesterase

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P3221
Unit cell:
a: 147.654Å b: 147.654Å c: 142.298Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.251 0.295
Expression system: Spodoptera frugiperda