5e8g

X-ray diffraction
2.7Å resolution

Crystal structure of the DNA binding domain of human transcription factor FLI1

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Friend leukemia integration 1 transcription factor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 128 amino acids
Theoretical weight: 14.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01543 (Residues: 276-399; Coverage: 27%)
Gene name: FLI1
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: R3
Unit cell:
a: 140.551Å b: 140.551Å c: 85.14Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.196 0.248
Expression system: Escherichia coli BL21(DE3)