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Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN6

Source organism: Mus musculus
Biochemical function: zinc ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13927
Domain description: Immunoglobulin domain
Occurring in:
  1. Contactin-6
The deposited structure of PDB entry 5e5u contains 4 copies of Pfam domain PF13927 (Immunoglobulin domain) in Contactin-6. Showing 2 copies in chain B.

PF00194
Domain description: Eukaryotic-type carbonic anhydrase
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase gamma
The deposited structure of PDB entry 5e5u contains 2 copies of Pfam domain PF00194 (Eukaryotic-type carbonic anhydrase) in Receptor-type tyrosine-protein phosphatase gamma. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001148
Domain description: Alpha carbonic anhydrase domain
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase gamma
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. Contactin-6
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Contactin-6
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Contactin-6
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Contactin-6
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Contactin-6
IPR036398
Domain description: Alpha carbonic anhydrase domain superfamily
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase gamma
IPR043204
Domain description: Basigin-like
Occurring in:
  1. Contactin-6
IPR041887
Domain description: Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domain
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase gamma
IPR023561
Domain description: Carbonic anhydrase, alpha-class
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase gamma

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Contactin-6
The deposited structure of PDB entry 5e5u contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Contactin-6. Showing 2 copies in chain B.
3.10.200.10
Class: Alpha Beta
Architecture: Roll
Topology: Carbonic Anhydrase II
Homology: Alpha carbonic anhydrase
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase gamma
The deposited structure of PDB entry 5e5u contains 2 copies of CATH domain 3.10.200.10 (Carbonic Anhydrase II) in Receptor-type tyrosine-protein phosphatase gamma. Showing 1 copy in chain A.

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