5e4j

X-ray diffraction
2.54Å resolution

Function and Biology Details

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 532 amino acids
Theoretical weight: 60.19 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P04058 (Residues: 25-556; Coverage: 94%)
Gene name: ache
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3121
Unit cell:
a: 111.21Å b: 111.21Å c: 137.03Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.191 0.229